Four-Component Domino Reaction for the Synthesis of 1-(1H-Indol-2-yl)-1H-pyrazolo[1,2-b]phthalazine-5,10-diones |
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| Authors: | Y Dathu Reddy B Surya Narayana Ch Venkata Ramana Reddy P K Dubey |
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| Institution: | Department of Chemistry , Jawaharlal Nehru Technological University, Hyderabad College of Engineering , Hyderabad , India |
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| Abstract: | Facile, efficient, four-component domino reaction of dialkylphthalates, hydrazine hydrate, indole-3-carboxaldehydes, and malononitrile/ethyl cyanoacetate leads to the formation of 1-(1H-indol-2-yl)-1H-pyrazolo 1,2-b] phthalazine-5,10-diones in the presence of InCl3 as catalyst in refluxing ethanol for 1 h in good yields. This four-component domino reaction transformation presumably proceeds via sequential addition, dehydration, condensation, and cyclization steps. |
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| Keywords: | Domino reaction ethanol green synthesis InCl3 |
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