Metal-Free,One-Pot Oxidative Conversion of Aldehydes to Primary Thioamides in Aqueous Media |
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Authors: | Arvind K Yadav Vishnu P Srivastava |
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Institution: | Green Synthesis Laboratory, Department of Chemistry , University of Allahabad , Allahabad , India |
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Abstract: | One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water. Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
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Keywords: | Aldehydes deoxygenation green chemistry nitriles O O-diethyl dithiophosphopric acid thioamides |
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