Methyltrichlorosilane as an Effective Activation Agent for Swern Oxidation |
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| Authors: | Yuanxun Wang |
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| Institution: | 1. Natural Products Research Center , Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu , China;2. University of Chinese Academy of Sciences , Beijing , China |
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| Abstract: | A practical and efficient alternative version of the Swern oxidation has been successfully developed. Methyltrichlorosilane was used as an efficient activator of dimethylsulfoxide, which could oxidize a wide range of primary and secondary alcohols to the corresponding carbonyl compounds with good to excellent yields. |
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| Keywords: | Alcohols carbonyl compounds MeSiCl3–DMSO silicon reagents Swern oxidation |
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