Synthesis and Characterization of Some Novel Multisubstituted 6,7-Dihydro-5H-cyclopenta[b]pyridine Derivatives |
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Authors: | Meliha Burcu Gürdere Burhan Yilmaz Yakup Budak |
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Institution: | Department of Chemistry, Faculty of Arts and Sciences , Gaziosmanpasa University , Tokat , Turkey |
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Abstract: | In this study, we describe systematic preparation of a series of aryl-substituted pyridine derivatives. The 1,5-dicarbonyls (3a–i) were prepared in the solvent-free conditions starting from chalcone derivatives (1a–i). The target compounds, 4-aryl-2-(thiophen-3-yl)-6,7-dihydro-5H-cyclopentab]-pyridine derivatives (5a–i), were synthesized by a cyclization reaction of the 1,5-dicarbonyls (3a–i) with ammonium acetate (NH4OAc) in acetic acid. The characterization of synthesized compounds was proved by elemental analyses, infrared, mass spectrometry, and 1H and 13C NMR spectroscopy. Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
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Keywords: | 4-Aryl-2-(thiophen-3-yl)-6 7-dihydro-5H-cyclopenta[b]-pyridine chalcone 1 5-dicarbonyl |
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