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An amine-derivatized, DOTA-loaded polymeric support for Fmoc solid phase peptide synthesis |
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| Authors: | Byunghee Yoo Mark D. Pagel |
| Affiliation: | a Biomedical Engineering Interdisciplinary Program, The University of Arizona, Tucson, AZ, USA b Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA c Department of Chemistry, The University of Arizona, Tucson, AZ, USA |
| Abstract: | An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional solid phase peptide synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents. |
| Keywords: | DOTA SPPS Fmoc PARACEST MRI Molecular Imaging |
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