In-situ formation of 2H phase MoS2/cerium-zirconium oxide nanohybrid for potential electrochemical detection of an anticancer drug flutamide |
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| Authors: | SV Selvi N Nataraj T-W Chen SM Chen S Nagarajan CS Ko T-W Tseng C-C Huang |
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| Institution: | 1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung?Hsiao East Road, Taipei 106, Taiwan, ROC;2. Research and Development Center for Smart Textile Technology, National Taipei University of Technology, Taipei 106, Taiwan, ROC;3. Department of Materials, Imperial College London, London, SW72AZ, United Kingdom;4. Department of Chemistry, National Institute of Technology, Manipur, India;5. Department of Bioscience and Biotechnology, National Taiwan Ocean University, 2, Beining Road, Keelung 20224, Taiwan |
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| Abstract: | The developing field of sensors is highly motivated and attracted by two-dimensional transition metal dichalcogenides (TMDs) with transition metal oxide integration. Initially, molybdenum disulfide (MoS2), one among the TMDs with cerium-zirconium oxide (CZO), was one-pot synthesized via hydrothermal method for sensing flutamide (FLD). The as-synthesized hybrid nanocomposite was characterized to understand their physical and chemical presence. MoS2-CZO was well assigned with crystalline nature observed from X-ray powder diffraction and X-ray photoelectron spectroscopy. High-resolution transmission electron microscopy confirms the irregularly arranged nanoparticles wrapped with MoS2 sheets. The wide surface area with more electroactive sites has provided higher conductance of the MoS2-CZO/glassy carbon electrode. The limit of detection was 0.005 μM with a linear range of 0.019 μM to 668.5 μM, sensitivity 0.353 μA μM?1 cm?2. The practical feasibility was analyzed with human urine and river water samples, whereas the obtained results showed excellent FLD detection. The fabricated MoS2-CZO with all these distinguished analyses will be an outbreak in the field of electrochemical sensors. |
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| Keywords: | Metal chalcogenides Layered structure Metal oxide composite Real samples |
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