| 新型苯并咪唑衍生物的合成 |
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| 引用本文： | 何冠宁,袁斌,贾群坡,吕松.新型苯并咪唑衍生物的合成[J].合成化学,2022,30(2):107-112. |
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| 作者姓名： | 何冠宁 袁斌 贾群坡 吕松 |
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| 作者单位： | 广东工业大学 环境科学与工程学院，广东 广州 510006 |
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| 基金项目： | 广东省科技计划项目(2016A020221035)。 |
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| 摘 要： | 以苯甲醛甘油缩醛和对甲基苯甲醛甘油缩醛为原料，采用次氯酸钠催化氧化法，制得2-芳基-4-羧基-1,3-二氧戊环中间体;中间体分别与邻苯二胺或N-甲基邻苯二胺反应，合成了4种新型苯并咪唑衍生物(3a~3d)，收率为78.0%~80.5%,其结构经UV, 1H NMR, 13C NMR, IR和HR-MS(ESI)表征。
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| 关 键 词： | 甘油缩醛 苯并咪唑 1 3-二氧戊环 邻苯二胺 合成 催化氧化 |
| 收稿时间： | 2019-04-01 |
Synthesis of Novel Benzimidazole Derivatives |
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| HE Guan-ning,YUAN Bin,JIA Qun-po,LV Song.Synthesis of Novel Benzimidazole Derivatives[J].Chinese Journal of Synthetic Chemistry,2022,30(2):107-112. |
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| Authors: | HE Guan-ning YUAN Bin JIA Qun-po LV Song |
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| Institution: | Faculty of Environmental Science and Engineering, Guangdong University of Technology,
Guangzhou 510006, China |
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| Abstract: | The intermediates of 2-aryl-1,3-dioxolame-4-carboxyl acid were synthesized by the catalytic oxidation method of sodium hypochlorite using benzaldehyde glycerol acetal and p-methylbenzaldehyde glycerin acetal as raw material.Four novel benzimidazole derivatives were synthesized efficiently by the intermediate reacted with o-phenylenediamine or N-methyl-o-phenylenediamine respectively.Compounds 3a,3b,3c,3d were new substances.The yields were 79.5%,78.0%,80.5%and 78.0%,respectively.The structures were characterized by UV-Vis,1H NMR,13C NMR,IR and HR-MS(ESI).The synthesis conditions of new compounds were optimized by orthogonal test. |
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| Keywords: | glycerol acetal benzimidazole 1 3-dioxolane o-phenylenediamine synthesis catalytic oxidation |
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