Synthesis of alkylated methylene bisphosphonates via organothallium intermediates |
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| Authors: | David W. Hutchinson Graeme Semple |
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| Affiliation: | Department of Chemistry, University of Warwick, Coventry, West Midlands, CV4 7AL Great Britain |
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| Abstract: | Thallium(I) derivatives of esterified methylene bisphosphonates can be readily obtained by treating the latter with thallium(I) ethoxide under anhydrous conditions. Alkylation of the thallium(I) derivatives by a range of primary alkyl iodides takes place smoothly, and significantly higher yields are obtained than for the corresponding reactions with lithio or sodio derivatives. |
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| Keywords: | A qui toute correspondance devrait être adressée |
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