| Synthetic Channel-forming Peptides and Ion Selectivity |
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| 引用本文： | GUO Li-li WANG Dong-xia Roger W. Roeske. Synthetic Channel-forming Peptides and Ion Selectivity[J]. 高等学校化学研究, 2006, 22(2): 265-266. DOI: 10.1016/S1005-9040(06)60094-9 |
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| 作者姓名： | GUO Li-li WANG Dong-xia Roger W. Roeske |
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| 作者单位： | Department of |
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| 摘 要： | Introduction PeptidesmadeupofalternatingL andD amino acidscanformβhelicesasingramicidinAorcyclic peptidesthataggregatetoformtubes[1].Inbothcases thestructuresarehollowwithallthesidechainspro jectingoutwards.Kennedyetal.[2]postulatedthat peptideshavingthe…
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| 关 键 词： | 循环缩氨酸 离子通道 离子选择性 D-氨基酸 短杆菌肽 |
| 文章编号： | 1005-9040（2006）-02-265-02 |
| 收稿时间： | 2005-12-20 |
Synthetic Channel-forming Peptides and Ion Selectivity |
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| Li-li GUO, Dong-xia WANG,Roger W. Roeske. Synthetic Channel-forming Peptides and Ion Selectivity[J]. Chemical Research in Chinese University, 2006, 22(2): 265-266. DOI: 10.1016/S1005-9040(06)60094-9 |
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| Authors: | Li-li GUO Dong-xia WANG Roger W. Roeske |
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| Affiliation: | aDepartment of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN 46–202, USA |
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| Abstract: | Introduction Peptides made up of alternating L- and D- amino acids can form β-helices as in gramicidin A or cyclic peptides that aggregate to form tubes[1]. In both cases the structures are hollow with all the side chains projecting outwards. Kennedy et al. [2] postulated that peptides having the (LLLD)n configuration could form helices with every fourth side chain projecting inward.It is a fact that synthetic N-formyl-( LeuSerLeuGly)6-OH, when added to a lipid bilayer, dimerizes, to form ion channels having conductances greater than that of gramicidin. |
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| Keywords: | Cyclic peptide Ion channels Ion selectivity |
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