Synthesis of homoallylic amines via the palladium-catalyzed decarboxylative coupling of amino acid derivatives |
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Authors: | Burger Erin C Tunge Jon A |
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Affiliation: | University of Kansas, Department of Chemistry, 2010 Malott Hall, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA. |
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Abstract: | Protected homoallylic amines are synthesized by the decarboxylative coupling of alpha-amino acid derivatives. The catalytic C-C bond-forming reaction relies on the bioinspired decarboxylative metalation of alpha-amino acids to produce alpha-amino anion equivalents. The alpha-amino anion equivalents are intercepted by pi-allyl palladium electrophiles to produce substituted homoallylic amines. |
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