Regioselective Rh-catalyzed direct carbonylation of indoles to synthesize indole-3-carboxylates |
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| Authors: | Lang Rui Wu Junliang Shi Lijun Xia Chungu Li Fuwei |
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| Institution: | State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China. |
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| Abstract: | Rh-catalyzed C-H carbonylation of indoles under 1 atm of CO has been achieved. Various substituted indoles and indole with free N-H could be carboxylated with linear- and/or cyclic-alcohol to give the desired indole-3-carboxylates with up to 92% yield. A mechanism involving Rh(III) initiated C-H metallation is proposed. |
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