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Antifungal cyclopentenediones from Piper coruscans
Authors:Li Xing-Cong  Ferreira Daneel  Jacob Melissa R  Zhang Qifeng  Khan Shabana I  ElSohly Hala N  Nagle Dale G  Smillie Troy J  Khan Ikhlas A  Walker Larry A  Clark Alice M
Affiliation:National Center for Natural Products Research, Mississippi, USA. xcli7@olemiss.edu
Abstract:Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida albicans and its azole-resistant strains and may serve as a template for a new class of antifungal agents.
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