Highly efficient and diastereoselective synthesis of (+)-lineatin |
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| Authors: | Alibés Ramon de March Pedro Figueredo Marta Font Josep Racamonde Marta Parella Teodor |
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| Institution: | Departament de Química and Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. |
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| Abstract: | reaction: see text] A linear sequence was used to synthesize (+)-lineatin in 14 steps and 14% overall yield from a homochiral 2(5H)-furanone. Key steps of this synthetic approach feature the diastereoselective construction of a cyclobutene through a photochemical 2 + 2] cycloaddition and a regiocontrolled oxymercuration reaction. |
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