Stereoselective total synthesis of antitumor macrolide (+)-rhizoxin D |
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| Authors: | Jiang Yueheng Hong Jian Burke Steven D |
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| Institution: | Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1396, USA. |
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| Abstract: | structure: see text] A convergent, stereoselective total synthesis of the macrolide antitumor agent rhizoxin D is described. (+)-DIPCl-promoted asymmetric aldol reaction, Evans-Tishchenko 1,3-diol synthesis, modified Julia coupling, and Horner-Wadsworth-Emmons reactions are featured. |
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