Ligand effects in the synthesis of N-heterocycles by intramolecular Heck reactions |
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Authors: | Cropper Emma L White Andrew J P Ford Agnes Hii King Kuok Mimi |
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Institution: | Department of Chemistry, Imperial College London, Exhibition Road, South Kensington SW7 2AZ, United Kingdom. |
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Abstract: | Chemo- and regioselectivity of intramolecular Heck reactions are dependent on the type of ligand employed. Six- to eight-membered benzolactams are produced in good yields using PPh3 as ligand. In contrast, a biaryl coupling occurred preferentially under ligandless conditions to form a dihydrophenanthridine product. Conformations of the seven- and eight-membered benzolactams in the solid state were examined by X-ray crystallography. |
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