|
|||||
|
|
Design,Synthesis, and Anticancer Activity of Amide Derivatives of Structurally Modified Combretastatin-A4 |
|
| Authors: | Ragha Suma V Sreenivasulu R Subramanyam M Rao K Ram Mohan |
| Institution: | 1.Department of Chemistry, GITAM Institute of Science, Gandhi Institute of Technology and Management, (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, 530045, India ;2.Department of Chemistry, Government Degree and PG College, Bhadrachalam, Telangana, 507111, India ;3.Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India ;4.Department of Chemistry, SR and BGNR Govt. Arts and Science College (Autonomous), Khammam, Telangana, 507002, India ;5.Department of Chemistry, GITAM Institute of Technology, Gandhi Institute of Technology and Management, Rushikonda, Visakhapatnam, Andhra Pradesh, 530045, India ; |
| Abstract: | A new series of amide derivatives of structurally modified combretastatin-A4 10a–10j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. The products are tested for their anticancer activity towards human cancer cell lines, MCF-7 (breast), A-549 (lung), Colo-205 (colon), and A-2780 (ovarian). The compounds 10b, 10c, and 10d demonstrate the most promising activity. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |