| Asymmetric Hydrogenation of α-Hydroxy Ketones: A Reaction Sensitive toward Electronic Effect of Substrates |
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| 引用本文： | XU Hui,MENG Qing-Hua,ZHANG Zhao-Guo,. Asymmetric Hydrogenation of α-Hydroxy Ketones: A Reaction Sensitive toward Electronic Effect of Substrates[J]. 中国化学, 2008, 26(9): 1656-1658. DOI: 10.1002/cjoc.200890299 |
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| 作者姓名： | XU Hui MENG Qing-Hua ZHANG Zhao-Guo |
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| 作者单位： | a School of Chemistry and Chemical Technology, Shanghai Jiaotong University, Shanghai 200240, China ;b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China ; |
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| 摘 要： | 以[RuCl2(benzene)]2 和 SunPhos为原料现场制备的催化剂，催化不对称氢化α-羟基酮类化合物可获得手性1, 2-二醇类化合物，ee值最高达99%。
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| 关 键 词： | 不对称氢化 α-羟基酮 催化 钌 1 2-二醇 |
| 收稿时间： | 2008-01-25 |
| 修稿时间： | 2008-04-27 |
Asymmetric Hydrogenation of α‐Hydroxy Ketones: A Reaction Sensitive toward Electronic Effect of Substrates |
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| Hui XU,Qing‐Hua MENG,Zhao‐Guo ZHANG. Asymmetric Hydrogenation of α‐Hydroxy Ketones: A Reaction Sensitive toward Electronic Effect of Substrates[J]. Chinese Journal of Chemistry, 2008, 26(9): 1656-1658. DOI: 10.1002/cjoc.200890299 |
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| Authors: | Hui XU Qing‐Hua MENG Zhao‐Guo ZHANG |
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| Affiliation: | 1. School of Chemistry and Chemical Technology, Shanghai Jiaotong University, Shanghai 200240, China;2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;3. Tel.: 0086‐021‐54748925;4. Fax: 0086‐021‐54748925 |
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| Abstract: | An efficient asymmetric hydrogenation of α‐hydroxy ketones was reported with the catalyst prepared from [RuCl2(benzene)]2 and SunPhos, chiral terminal 1,2‐diols were obtained in up to 99% ee. This Ru‐catalyzed asymmetric hydrogenation reaction of α‐hydroxy ketones represents a new route for the synthesis of chiral terminal 1,2‐diols. |
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| Keywords: | asymmetric hydrogenation hydroxy ketone, catalysis ruthenium terminal 1,2‐diol |
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