| 基于泡沫分馏技术立体选择拆分蛋氨酸外消旋体 |
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| 引用本文： | 李琳,马国恒,陈晓青,焦飞鹏,黄笃树.基于泡沫分馏技术立体选择拆分蛋氨酸外消旋体[J].分析科学学报,2010,26(4). |
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| 作者姓名： | 李琳 马国恒 陈晓青 焦飞鹏 黄笃树 |
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| 作者单位： | 1. 中南大学化学化工学院,湖南长沙,410083
2. 云南蒙自红河学院理学院,云南蒙自,661100 |
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| 基金项目： | 国家自然科学基金，湖南省自然科学基金重点项目，中南大学大学生创新性实验计划 |
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| 摘 要： | 以青霉素G钾盐(PEN-K)为手性捕集剂,十二烷基硫酸钠(SDS)为起泡剂,采用泡沫分馏技术对蛋氨酸外消旋体进行拆分,采用正交实验法考察了回流时间(A)、溶液pH值(B)、柱填料高度(C)、回流气速(D)和待分馏溶液中各物质浓度比(E)等对拆分性能的影响。通过直观分析和方差分析研究可知,五因素中对对映体过量值影响次序为:DEBAC,从而得到拆分蛋氨酸外消旋体的优化工艺条件为D2E2B1A4C4。在回流时间60min、溶液pH值2.0、柱填料高度28cm、回流气速40L/h、溶液中各物质浓度比60∶1∶0.6的条件下得到的对映体过量值为50.0。
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| 关 键 词： | 泡沫分馏 蛋氨酸外消旋体 拆分 青霉素G钾盐 十二烷基硫酸钠 |
Enantioselective Resolution of Racemic Methionine Based on Bubble Fractionation |
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| LI Lin,MA Guo-heng,CHEN Xiao-qing,JIAO Fei-peng,HUANG Du-shu.Enantioselective Resolution of Racemic Methionine Based on Bubble Fractionation[J].Journal of Analytical Science,2010,26(4). |
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| Authors: | LI Lin MA Guo-heng CHEN Xiao-qing JIAO Fei-peng HUANG Du-shu |
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| Institution: | LI Lin1,MA Guo-heng1,CHEN Xiao-qing1,JIAO Fei-peng1,HUANG Du-shu2(1.School of Chemistry and Chemical Engineering,Central South University,Changsha 410083,2.School of Science,Honghe University,Mengzi 661100) |
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| Abstract: | A method of bubble fractionation,using benzylpenicillin potassium (PEN-K) as a chiral collector and sodium dodecyl sulfate (SDS) as a foamer,was developed for the resolution of racemic methionine (racMet). Orthogonal experiment was performed in the research of enantioselectivity of Met,the influence of reflux equilibration time (A),pH of solution (B),packing height (C),gas flow rate (D) and concentration ratio of different substances in solution on resolution performances were investigated. It is found with... |
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| Keywords: | Bubble fractionation Racemic methionine Resolution Benzylpenicillion potassium Sodium dodecyl sulfate |
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