| meso—四—（取代苯基）卟吩衍生物产生单线态氧的ESR研究 |
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| 引用本文： | 陈暨耀,许德余.meso—四—（取代苯基）卟吩衍生物产生单线态氧的ESR研究[J].高等学校化学学报,1991,12(7):970-972. |
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| 作者姓名： | 陈暨耀 许德余 |
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| 作者单位： | 复且大学物理系、分析测试中心，复且大学物理系、分析测试中心，复且大学物理系、分析测试中心，复且大学物理系、分析测试中心，第二军医大学抗疟药研究室，第二军医大学抗疟药研究室 上海 200433，上海 200433，上海 200433，上海 200433 |
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| 摘 要： | 随着肿瘤光动力疗法(Photodynamic Therapy,PDT)的不断发展,出现了一系列新光敏剂,其中,meso-四-(取代苯基)卟吩衍生物是一类肿瘤选择性摄入率高、理化性质稳定的光动力敏化剂,近年来,作者设计并合成了一组meso-四-(取代苯基)卟吩衍生物,并初步观察了它们对细胞及小鼠移植瘤的光动力学效应,为了进一步比较不同卟吩衍生物的光敏化
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| 关 键 词： | 卟吩 单线态氧 ESR 肿瘤 光敏剂 |
ESR Studies on Singlet Oxygen Generation of Meso-Tetrakis-(substituted phenyl) Porphine Derivatives |
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| Chen Ji-yao,Lu Ya-meng,Chen Shi-ming,Cai Huai-xin.ESR Studies on Singlet Oxygen Generation of Meso-Tetrakis-(substituted phenyl) Porphine Derivatives[J].Chemical Research In Chinese Universities,1991,12(7):970-972. |
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| Authors: | Chen Ji-yao Lu Ya-meng Chen Shi-ming Cai Huai-xin |
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| Abstract: | The ability of meso-tetrakis- (substituted phenyl) porphine derivatives for photo-generating singlet oxygen (1O2) is studied by ESR spectrometry. The results show that the singlet oxygen yields of most of porphine derivatives are higher than that of HPD. It is also exhibited that the nature and structure of the substituent at the meso position are closely related to the photosensitizing ability of meso-te-trakis-(substituted phenyl) porphines. |
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| Keywords: | Porphine Singlet oxygen Electron spin resonance |
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