as-Triazin-Derivate,die möglicherweise therapeutische Wirkung besitzen, 15. Mitt.: Synthese von neuen “blockierten 5-substituierten 4-thio-6-azauridinen” |
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Authors: | Dr. Carol Cristescu |
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Affiliation: | (1) Chemisch-Pharmazeutisches Forschungsinstitut, 112 Vitanstr, Bukarest 4, Rumänien |
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Abstract: | 5-Substituted 4-thio-6-azauracils [I, 6-alkylthio-3,4-dihydro-5-thioxo-1,2,4-triazin-3(2H)-ones] have been converted with hexamethyldisilazane in 3-trimethylsilyloxy-5-trimethylsilylthio-derivatives(II). These were condensed with 1-O-acetyl-2,3,5-tri-O-benzoyl-d-ribofuranose in the presence of anhydrous stannic chloride to afford the corresponding 1-(2 ,3 ,5 -tri-O-benzoyl- -d-ribofuranosyl)-4-thioxo-5-substituted-6-azauracil (III). |
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