Transient DSC,a Novel and Rapid Method for Assessing Pharmaceutical Powder Compacts |
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| Authors: | Ozao R Ochiai M Ichimura Y Takahashi H Takano T |
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| Institution: | (1) North Shore College of SONY Institute, Atsugi, 243-8501;(2) Seiko Instruments Inc., Chiba, 261-8507;(3) Waseda University, Tokyo 169-8555, Japan |
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| Abstract: | The previously described method involving the use of transient DSC was applied to pharmaceutical powder compacts and to ceramic
powder compacts. The samples were prepared by compressing powders of pentaerythritol tetraacetate and two kinds of alumina
powder (differing in particle size distribution) up to a pressure of 20 MPa by using a jig. For pentaerythritol tetraacetate,
a linear relationship was obtained between the parameter obtained by DSC and the compaction pressure.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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| Keywords: | alumina aluminum oxide compact DSC particles pentaerythritol tetraacetate pharmaceuticals powder thermal resistance transient state |
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