Decomposition rates of radiopharmaceutical indium chelates in serum |
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Authors: | S M Yeh C F Meares D A Goodwin |
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Institution: | (1) Chemistry Department, University of California, 95616 Davis, California, USA;(2) Stanford University School of Medicine, 94304, California, USA;(3) Department of Nuclear Medicine, Veterans Administration Medical Center, 94304 Palo Alto, California, USA |
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Abstract: | The rates at which six small aminopolycarboxylate chelates of trivalent111In and three protein-bound chelates of111In deliver indium to the serum protein transferrin have been studied in sterile human serum at pH 7.3, 37°C. Sterically hindered
chelates containing a substituent on an ethylene carbon of EDTA decompose with rates in the range 0.03 to 0.11% per day—one
to two orders of magnitude slower than other chelates. Only small differences are observed between rates of decomposition
for low-molecular-weight chelates and for protein-bound chelates having analogous structures. |
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