Pyranmycins,a novel class of aminoglycosides with improved acid stability: the SAR of D-pyranoses on ring III of pyranmycin |
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| Authors: | Chang Cheng-Wei Tom Hui Yu Elchert Bryan Wang Jinhua Li Jie Rai Ravi |
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| Institution: | Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, USA. chang@cc.usu.edu |
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| Abstract: | reaction: see text] The synthesis of a novel class of aminoglycosides, pyranmycins, is reported along with the structure activity relationship (SAR) of their antibacterial activity against Escherichia coli. Two pyranmycins show prominent activity (9 microM). Pyranmycins also manifest superior stability in acidic media. The SAR information will lead to the future designs of pyranmycin against drug resistant bacteria. |
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