Stereoselective transformation of indole diazabicyclo[3.2.2]nonedione to azepinoindole |
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| Authors: | Orain David Denay Régis Koch Guido Giger Rudolf |
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| Institution: | Novartis Pharma AG, Core Technology, Combinatorial Chemistry Unit, WSJ-507.7.04 Lichtstrasse 35, CH-4056 Basel, Switzerland. |
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| Abstract: | reaction: see text] The synthesis of an indole diazabicyclo3.2.2]nonedione derivative was achieved in a few steps starting from L-tryptophan. Reduction with borane-THF complex leads to fragmentation of the bicycle and the stereoselective formation of an azepinoindole derivative was observed. |
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