Studies on the synthesis of tedanolide. 2. Stereoselective synthesis of a protected C(1)-C(12) fragment |
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| Authors: | Roush William R Newcom Jason S |
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| Institution: | Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. roush@umich.edu |
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| Abstract: | reaction: see text] Highly diastereoselective syntheses of diketo esters 6a and 6b are described. These intermediates undergo efficient aldol reactions with protected C(13)-C(21) aldehydes 3 and 23, thereby providing advanced C(1)-C(21) tedanolide seco ester precursors 9a and 9b. |
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