INDUCTION OF SISTER-CHROMATID EXCHANGES IN ICR 2A FROG CELLS EXPOSED TO 254 NM AND SOLAR UV WAVELENGTHS |
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Authors: | Chuck C.-K. Chao Barry S. Rosenstein |
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Affiliation: | Radiation Biology Section, Department of Radiology, The University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75235, USA |
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Abstract: | Abstract— Exposure of ICR 2A frog cells to 254 nm UV induced the formation of sister-chromatid exchanges (SCEs) in a fluence-dependent manner. Cells were also exposed to the UV produced by a fluorescent sunlamp that was filtered through 8C Mylar in order to simulate the mid-UV(290–320 nm) portion of sunlight reaching the earth's surface. In this instance, SCEs were induced in a linear fashion at low fluences but reached a plateau at a low level of induced SCEs. In addition, pretreatment of cells with the solar UV followed by exposure to 254 nm UV resulted in a significantly lower level of SCEs than in cells exposed to 254 nm UV alone. |
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