Highly regio- and stereoselective intramolecular 1,3-dipolar cycloadditions of norbornadiene-tethered nitrile oxides |
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| Authors: | Yip C Handerson S Jordan R Tam W |
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| Institution: | Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1. |
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| Abstract: | reaction: see text] Intramolecular cycloadditions with high regio- and stereocontrol are important methods for the efficient assembly of complex molecular structures. Efficient routes to the synthesis of norbornadiene-tethered nitrile oxides have been developed, and their intramolecular 1,3-dipolar cycloadditions were studied. The cycloadditions occurred in good yields for a variety of substrates and were found to be highly regio- and stereoselective. |
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