An efficient synthesis of the phytoestrogen 8-prenylnaringenin from isoxanthohumol with magnesium iodide etherate |
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| Authors: | Miros?aw Anio? Katarzyna Szymańska Anna ?o?nierczyk |
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| Institution: | Department of Chemistry, Wroc?aw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroc?aw, Poland |
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| Abstract: | Xanthohumol was isolated from supercritical carbon dioxide-spent hop and transformed into isoxanthohumol. The demethylation of isoxanthohumol with the best yield 93% occurred when MgI2 etherate in anhydrous THF was applied. Salts such as MgBr2, MgCl2, CaI2, Mg(OAc)2, Mg(OMe)2 were also investigated. A convenient method for the xanthohumol isolation from supercritical carbon dioxide-spent hop is also described. |
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| Keywords: | Xanthohumol Isoxanthohumol 8-Prenylnaringenin Phytoestrogen Demethylation Magnesium iodide etherate |
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