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Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid |
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| Authors: | Sharmistha Das M Mehedi Masud Lutfun Nahar Simon Gibbons Satyajit D Sarker |
| Institution: | a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh b Department of Pharmacy, University of Science & Technology Chittagong, Foy's Lake, Chittagong, Bangladesh c School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK d Centre for Pharmacognosy and Phytochemistry, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK e Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh |
| Abstract: | 6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice. |
| Keywords: | 3-Fluorophenylcyanoethylacrylate 3-Fluorophenyl succinic acid 6-Fluoro-3-oxo-indan-1-carboxylic acid 6-Fluoroindan-1-carboxylic acid Analgesic activity |
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