Zinc triflate-catalyzed synthesis of pyrazino[2,1-b]quinazoline-3,6-diones |
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Authors: | Ming-Chung Tseng |
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Affiliation: | Department of Chemistry and Biochemistry, National Chung Cheng University, 168 University Road, Chia-Yi 621, Taiwan, ROC |
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Abstract: | Using zinc triflate, the direct one-pot double cyclodehydration of linear tripeptides to the total synthesis of pyrazino[2,1-b]quinazoline-3,6-diones (1a-l) on solid support was achieved with good overall yields in short reaction time. These syntheses of the pyrazino[2,1-b]quinazoline-3,6-diones were conveniently achieved in only three steps, starting from the amino acid-bound Wang resin. |
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Keywords: | Zinc Triflate Cyclodehydration Anthranilic acid Peptide Pyrazino[2,1-b]quinazoline-3,6-dione |
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