Analysis of antibiotics from liquid sample using electrospray ionization-ion mobility spectrometry |
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Authors: | Shu Li Jian JiaXiaoguang Gao Xiuli HeJianping Li |
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Affiliation: | State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China |
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Abstract: | The recent findings of antibiotic residues in aquatic environment at trace level have gained much concern for the detrimental effect on ecological and human health due to bacterial resistance. Here, the feasibility of using electrospray ionization ion mobility spectrometry (ESI-IMS) for analysis antibiotics in liquid sample is demonstrated. Reduced mobilities and collision cross sections of 18 antibiotics are experimentally measured and compared with theoretical values according to mass-mobility correlation. Gentamicin is used as an example to investigate the capability of ESI-IMS for multi-component analysis of antibiotics. Mixtures of antibiotics at different concentrations are analyzed. The estimated detection limit for amoxicillin is 0.7 mg L−1 (70 pg) and the linear range of response maintains over two orders. This method will be a potential technique for the analysis of antibiotics in aquatic environment. |
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Keywords: | β-las, β-lactams amis, aminoglycosides macs, macrolides quis, quinolones suls, sulphanilamides tets, tetracyclines chls, chloramphenicols amo, amoxicillin amp, ampicillin ben, benzylpenicillin gen, gentamicin neo, neomycin str, streptomycin ery, erythromycin kit, kitasamycin tyl, tylosin lom, lomefloxacin ofl, ofloxacin pef, pefloxacin sde, sulfadimethoxine sdi, sulfadimidine sul, sulfanilamide dox, doxycycline oxy, oxytetracycline chl, chloramphenicol |
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