Nanoengineered micro gold shells for LDI-TOF analysis of small molecules |
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Authors: | Jeongwook Lee Juhee Lee Taek Dong Chung Woon-Seok Yeo |
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Affiliation: | 1. Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea;2. Department of Chemistry, Seoul National University, Seoul 151-747, Republic of Korea |
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Abstract: | This paper reports on analyses of small molecules with laser desorption/ionization time of flight (LDI-TOF) mass spectrometry (MS) using nanostructure-embedded micro gold shells (μAuSs). The mass analyses of amino acids, sugars, peptides, and their mixtures gave apparent mass peaks for analytes without any significant background interferences. μAuSs afforded a better limit of detection (LOD) and a higher signal-to-noise ratio than gold nanoparticles, which are commonly used for LDI-TOF analysis of small molecules. We believe μAuSs have advantages in terms of simplicity, detection limit, and reproducibility, and therefore, they constitute a significant addition to the organic matrix-free analytical tools that are currently in wide use. |
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Keywords: | LDI-TOF Matrix-free Micro gold shell SALDI Small molecule analysis |
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