Determination of oxytetracycline in milk samples by polymer inclusion membrane separation coupled to high performance liquid chromatography |
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| Authors: | Irma Pé rez-Silva,José A. Rodrí guez,Ma. Teresa Ramí rez-Silva,Ma. Elena Pá ez-Herná ndez |
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| Affiliation: | 1. Universidad Autónoma del Estado de Hidalgo, Área Académica de Química, Laboratorio 2, Carr. Pachuca-Tulancingo km. 4.5, C.P. 42184, Mineral de la Reforma, Hidalgo, Mexico;2. Universidad Autónoma Metropolitana-Iztapalapa, Área de Química Analítica, Laboratorio R-105, San Rafael Atlixco 186, Col. Vicentina, C.P. 09340, AP 55-534, D.F., Mexico |
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| Abstract: | The determination of oxytetracycline in milk samples using a polymer inclusion membrane concept with high performance liquid chromatography (HPLC) was studied. The membranes developed are composed by cellulose acetate as polymer base, Cyanex 923 as carrier and o-nitrophenyl octyl ether as plasticizer. In the optimal conditions, the method exhibits good linearity in the range 0.03–0.20 mg L−1 with a limit of detection and quantification of 8.2 and 27.3 μg L−1 respectively. The method was successfully applied to the analysis of milk samples with high selectivity. |
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| Keywords: | Cyanex® 923 Milk Oxytetracycline Plackett&ndash Burman experimental design Polymer inclusion membrane |
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