Synthesis,spatial structure,and biological activity of 1-AZA-4-oxabicyclo[4.1.0]heptan-5-ones |
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| Authors: | Eremeev A. V. Krutius O. N. Mishnev A. F. Bleidelis Ya. Ya. Liepin'sh É. É. Odynets A. G. Berzinya D. A. Kimenis A. A. |
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| Affiliation: | (1) Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006 Riga |
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| Abstract: | It has been found that the reaction of  - and  -amino alcohols with methyl 1,2-dibromopropionate results in the formation of esters of 1-(hydroxyalkyl)aziridine-2-carboxylic acids or 1-aza-4-oxabicyclo[4.1.0]pentan-5-ones, depending on the nature of the original reactants. An x-ray structural analysis of this new bicyclic system has been carried out. The hepatoprotector activity of the new compounds has been studied.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1349–1354, October, 1984. |
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