An efficient catalyst system for the asymmetric transfer hydrogenation of ketones: remarkably broad substrate scope |
| |
Authors: | Reetz Manfred T Li Xiaoguang |
| |
Institution: | Max-Planck Institut für Kohlenforschung, Mülheim/Ruhr, Germany. reetz@mpi-muelheim.mpg.de |
| |
Abstract: | A BINOL-derived diphosphonite having a xanthene backbone is an excellent bidentate ligand in Ru-catalyzed 2-propanol-based transfer hydrogenation of aryl/alkyl and alkyl/alkyl ketones (ee = 76-99%). Even notoriously difficult ketones such as isopropyl methyl ketone are reduced with extraordinarily high enantioselectivity (ee = 99%). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |