Total synthesis of hyacinthacine A1 and 3-epi-hyacinthacine A1 |
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| Authors: | Chabaud Laurent Landais Yannick Renaud Philippe |
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| Affiliation: | Laboratoire de Chimie Organique et Organométallique, Université Bordeaux-I, 351, Cours de la Libération, F-33405 Talence Cedex, France. |
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| Abstract: | [reaction: see text] Total synthesis of hyacinthacine A(1) and its epimer at C3 is described. The synthesis includes a stereocontrolled carboazidation of a chiral allylsilane as a key step. C-Si bond oxidation and reduction of the azide, with ring-closure, complete the total synthesis, which establishes the absolute configuration of 3. |
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