Expanding the scope of Mn(OAc)3-mediated cyclizations: synthesis of the tetracyclic core of tronocarpine |
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Authors: | Magolan Jakob Kerr Michael A |
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Affiliation: | Department of Chemistry, University of Western Ontario, London, Ontario, Canada N6A 5B7. |
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Abstract: | Pyrroles, indoles, and surprisingly, indolines, when equipped with a pendant malonyl group on the nitrogen atom, were effective substrates in a Mn(III)-mediated oxidative cyclization reaction, yielding the 1,2-annulated products in good to excellent yields. When indole acetonitrile was used as a substrate this method provided a rapid synthesis of a tetracyclic tronocarpine subunit. |
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