A polarographic and voltammetric study of some primary,secondary and tertiary thioamides of pharmaceutical importance |
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Authors: | Ian E Davidson WFranklin Smyth |
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Institution: | Wyeth Laboratories, Huntercombe Lane South, Taplow, Maidenhead, Berkshire, SL6 0PH Gt. Britain;Department of Chemistry, University College of Cork Republic of Ireland |
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Abstract: | The d.c. polarographic, and cyclic and cathodic stripping voltammetric behaviour of some primary, secondary and tertiary thioamides based on tetrahydroquinoline, is described. Catalytic reduction occurs in all cases; the primary and secondary thioamides undergo anodic oxidation and cathodic stripping, with the formation of mercury(II) sulphide. Tertiary thioamides are not amenable to anodic electrolysis/stripping. Mechanisms for these oxidation and reduction processes are postulated. Differential pulse polarography has a limit of detection of 5 × 10?7 M. Cathodic stripping voltammetry can be applied with a detection limit of 2 × 10?8 M. |
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