The photodimerization of aceanthrylene |
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| Institution: | 1. Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA;2. Cancer Innovation Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA;3. Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel;4. Institute for Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, Währinger Straße 10, 1090 Vienna, Austria;5. SAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa;6. Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;7. Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;8. University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France;9. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA;10. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou 510060, PR China |
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| Abstract: | Sensitized photodimerization of aceanthrylene (AA) with Rose Bengal in methanol produced both syn and anti head-to-head and head-to-tail stereoisomers with slight preference for syn adducts. The stereochemical configurations were assigned by deuterium labeling and by high field homonuclear shift correlation (COSY) experiments and these compare favorably with the assignments made for the photodimers of 1-substituted acenaphthylenes. Currently, AA has photodimerized under direct irradiation only in carbon disulfide. |
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