Synthetic studies toward verrucosidin: Determination of the absolute configuration |
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| Institution: | 1. Hebei University of Technology, Tianjin 300100, China;2. Tianjin Tasly Academy, Tasly Holding Group Co., Ltd., Tianjin 300410, China;3. State Key Laboratory of Core Technology in Innovative Chinese Medicine, Tasly Holding Group Co., Ltd., Tianjin 300410, China;1. Provincial Key Laboratory of Oil & Gas Chemical Technology, College of Chemistry and Chemical Engineering, Northeast Petroleum University, Da Qing, 163318, PR China;2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, CAS, Shanghai, 200032, PR China;1. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa K1N 6N5, Canada;2. Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA |
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| Abstract: | The tetrahydrofuran portion 3 of verrucosidin 1, a potent neurotoxin, is synthesized in an enantiomerically pure form via the stereoselective osmylation of the chiral hydroxy diene ester 5 as a key step. |
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