Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin. |
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| Affiliation: | 1. Biomolecular NMR Laboratory, Department of Biotechnology, University of Verona, Ca'' Vignal 1, Strada Le Grazie 15, 37134 Verona, Italy;2. Biocrystallography Laboratory, Department of Biotechnology, University of Verona, Ca'' Vignal 1, Strada Le Grazie 15, 37134 Verona, Italy |
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| Abstract: | A trialkoxy-diphenyl-methylester and amide linkage for solid-phase peptide synthesis with Fmoc strategy is described. Protected peptide esters can be smoothly cleaved with weak acid, resulting in fragments with intact side-chain protection. Mild acidic cleavage of the corresponding peptide amide resins yields peptide amides. |
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