Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs |
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| Authors: | Meng Li Fali Su Mingtao Zhu Huan Zhang Yuxin Wei Yang Zhao Jianmin Li Shaowa Lv |
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| Affiliation: | 1.Heilongjiang University of Chinese Medicine, Harbin 150040, China;2.Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China; (F.S.); (M.Z.); (H.Z.); (Y.W.); (Y.Z.);3.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China; |
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| Abstract: | Gambogic acid (GA) is a natural product with a wide range of pharmacological properties. It plays an important role in inhibiting tumor growth. A large number of GA derivatives have been designed and prepared to improve its shortcomings, such as poor water solubility, low bioavailability, poor stability, and adverse drug effects. So far, GA has been utilized to develop a variety of active derivatives with improved water solubility and bioavailability through structural modification. This article summarized the progress in pharmaceutical chemistry of GA derivatives to provide a reference and basis for further study on structural modifications of GA and expansion of its clinical applications. |
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| Keywords: | Gambogic acid structural modification derivative antitumor activity polymer prodrug |
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