The facile conversion of T-2 toxin and neosolaniol into anguidine |
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| Institution: | 1. State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China;2. Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China |
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| Abstract: | T-2 Toxin (5) and neosolaniol (6) are readily converted into anguidine (1) by a procedure where deoxygenation at the C-8 position is achieved, after conversion of the 3-TBDMS ether 7 of neosolaniol (6) to the β-bromide 11 for reduction to the anguidine precursor 12. |
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