The composition of primycin |
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| Affiliation: | 1. CHINOIN Pharm. Chem. Works Ltd., H-1325 Budapest, P.O.Box 110, Hungary;2. EGIS Pharmaceuticals, NMR Lab., H-1475 Budapest, P.O.Box 100, Hungary;3. Ottawa-Carleton Chemistry Institute, CARLETON Univ, Ottawa K1S 5B6, Canada;1. Hubei Key Laboratory of Natural Product Research and Development (China Three Gorges University), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, 443002, People’s Republic of China;2. College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Hebei University, Baoding 071002, People’s Republic of China;3. Hubei Engineering Research Center for Three Gorges Regional Plant Breeding, China Three Gorges University, Yichang 443002, People’s Republic of China;4. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf 40225, Germany;1. Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China;2. Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China;1. Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;2. Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;3. Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan;4. State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China;5. Fisheries and Oceans Hakodate, 3-1-1 Minato-cho, Hakodate 041-8611, Japan;1. Northwest Iowa Bone, Joint, & Sports Surgeons, 1200 1st Avenue E, Suite C, Spencer, IA 51301, USA;2. American Health Network Foot & Ankle Reconstructive Surgery Fellowship, 12188B North Meridian Street, Suite #330, Carmel, IN 46032, USA;3. SSM Health DePaul Hospital Foot and Ankle Surgery Residency, St Louis, MO, USA;4. SSM Health DePaul Hospital, 12303 DePaul Drive, Bridgeton, MO 63044, USA;1. University of California Santa Cruz, Cooperative Institute for Marine Ecosystems and Climate (CIMEC), Santa Cruz, USA;2. NOAA Southwest Fisheries Science Center, 110 McAllister Way, Santa Cruz, CA, 95060, USA;3. Department of Wildlife, Fish, and Conservation Biology, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA |
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| Abstract: | The macrolide antibiotic primycin is shown to consist of more than twenty compounds. Nine components, representing about 90 % of the total, have been isolated and their structures elucidated by spectroscopic methods. Molecular weights were determined by FAB mass spectrometry. The components studied belong to three groups (see Fig.), depending on substituent R2 and each set represents homologous series, differing in substituent R1. The structure proposed previously for primycin was unambiguously proved and assigned as that of the A1 component. |
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