Synthesis of nitro-substituted decalones by double Michael reaction,sequential Michael reaction,and by Diels-Alder reaction |
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| Institution: | 1. Department of Drug Design, University of Groningen, A. Deusinglaan 1, Groningen 9700 AD, The Netherlands;2. Carmolex Inc., Pittsburgh, USA;3. Technische Universität München, Germany |
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| Abstract: | 4-Nitro-3-phenyl-decalones are obtained from 1-acetylcyclohexene by three different ways. Stereochemistry and reaction pathways are discussed, and, for the first time, an intermediate of a sequential Michael reaction is isolated.The Michael reaction is of great preparative value for the formation of CC bonds2. We are especially interested in the stereochemistry of the double Michael reaction |
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