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1,3-dipolar cycloadditions to oxidopyraziniums
Affiliation:1. Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80–82, 6020 Innsbruck, Austria;2. Institut de Chimie Moléculaire de Reims (UMR CNRS 7312), SFR CAP''sANTE, UFR de Pharmacie, Université de Reims Champagne-Ardenne, BP 1039, 51687 Reims Cedex 2, France;1. Department of Medicinal Chemistry, Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA;2. WuXi AppTec (Wuhan) Co Ltd, 666 Gaoxin Road, East Lake High-tech Development Zone, Wuhan 430075, China;1. Instituto de Química, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva 700, 37130-000 Alfenas, MG, Brazil;2. Instituto de Química, Universidade Federal de Goiás, Campus Samambaia, CP 131, 74001-970 Goiânia, GO, Brazil;3. Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso (UFMT), CEP 78557-267, Campus Universitário de Sinop, Sinop, MT, Brazil;4. Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva 700, 37130-000 Alfenas, MG, Brazil
Abstract:1,5-Dimethyl-3-oxidopyrazinium (6) undergoes cycloadditions with methyl acrylate, acrylonitrile, diethyl maleate, maleimide, methyl propiolate and diethyl acetylenedicarboxylate.
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