Transition metal mediated organic synthesis: The synthesis of moracin M. |
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| Affiliation: | 1. ICI Plant Protection Division, Jealott''s Hill Research Station Bracknell, Berks RG12 6EY UK;2. Department of Chemistry, Imperial College, London SW7 2AY Canada;1. Division of Pediatric General and Thoracic Surgery, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;2. Division of Pathology and Laboratory Medicine, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;1. State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China;2. Department of Pharmacy, Quanzhou Medical College, Quanzhou 362100, China;3. College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Delta Region, Zhejiang University of Technology, Hangzhou 310014, China;4. College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China;1. Ecocompatible Asymmetric Catalysis Laboratory, Badji Mokhtar Annaba-University, B.P 12, 23000, Annaba, Algeria;2. Institute of Condensed Matter and Nanosciences, Molecules Solids and ReactiviTy (IMCN/MOST), Université Catholique de Louvain, Bâtiment Lavoisier, Pl. Louis Pasteur, 1, bte 3. 1348, Louvain La Neuve, Belgium |
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| Abstract: | The Palladium catalysed cross coupling of 2-halo- or metallo-benzofurans with both 5-metallo- or halo-resorcinol tricarbonyl chromium(O) complexes and the uncomplexed resorcinols, has been evaluated and in consequence, moracin M has been synthesised in good yield by the cross coupling of 6-(t-butyldiphenylsiloxy)-2-trimethylstannylbenzofuran with 5-iodoresorcinolbis(triisopropylsilyl) ether and fluoride ion deprotection of the product. |
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