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Continuous-flow solid-phase peptide synthesis |
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| Affiliation: | 1. Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA;2. Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA;3. Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA;4. Simpson Querrey Institute, Northwestern University, Chicago, IL, USA;5. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA |
| Abstract: | We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides. |
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