Approaches to avermectin assembly: Synthesis of the spiroketal system |
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| Affiliation: | 1. Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria;2. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1;3. Institute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria;4. Laboratoire des Glycochimie, des Antimicrobiens et des Agroressources (UMR 7378 CNRS), Université de Picardie Jules Verne, 33 Rue St Leu, 80039 Amiens, France |
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| Abstract: | A chiral synthesis of the spiroketal moiety of avermectin A2b has been accomplished in 14 steps from (3S(R), 4R(S))-3, 5-dimethyl-1-hexen-4-ol. |
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