New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles |
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Authors: | Maria E. Nikolaeva Andrey V. Nechaev Elena V. Shmendel Roman A. Akasov Mikhail A. Maslov Andrey F. Mironov |
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Affiliation: | 1.Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University, 86 Vernadsky Ave., 119571 Moscow, Russia; (A.V.N.); (E.V.S.); (A.F.M.);2.Federal Scientific Research Centre “Crystallography and Photonics” of RAS, 59 Leninsky Ave., 119333 Moscow, Russia; |
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Abstract: | Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF4 crystals doped with lanthanides Yb3+ and Er3+ were obtained by the high-temperature decomposition of trifluoroacetates in oleic acid and 1-octadecene. Such particles have pronounced hydrophobic properties. Therefore, to obtain stable dispersions in aqueous media for the study of their properties in vivo and in vitro, the polyethylene glycol (PEG)-glycerolipids of various structures were obtained. To increase the circulation time of PEG-lipid coated nanoparticles in the bloodstream, long-chain substituents are needed to be attached to the glycerol backbone using ether bonds. To prevent nanoparticle aggregation, an L-cysteine-derived negatively charged carboxy group should be included in the lipid molecule. |
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Keywords: | upconverting nanoparticles PEG-lipids surface modification |
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